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Clinical trials for advancing innovative interventions for neurodegenerative diseases
Horizon Europe · Cluster 1 – Health · HORIZON-HLTH-2027-02-DISEASE-14-TWO-STAGE
Funds early-stage clinical trials of combined therapeutic interventions for neurodegenerative diseases, excluding rare ones.
O čem je ta razpis?
The topic funds early-stage clinical trials of innovative interventions for neurodegenerative diseases that combine an active substance with complementary approaches such as lifestyle change or rehabilitation. Rare neurodegenerative diseases are excluded.
Kaj ta razpis financira?
Scope
The topic funds early-stage clinical trials of innovative interventions for neurodegenerative diseases. An intervention should combine a therapeutic solution based on an active substance with a complementary multidisciplinary approach, such as lifestyle changes, cognitive training or rehabilitation therapies. Rare neurodegenerative diseases are excluded. For pharmacological interventions, phase 1 and/or phase 2 trials apply.
Activities
Proposals should address most of the following:
- Rigorous early-stage trials on safety, efficacy and mode of administration, with adequate cohorts representing the patient population by age, sex and ethnicity.
- Insight into the mechanisms of action, for example through imaging and physiological, molecular or omics signatures, possibly leading to surrogate endpoints and more personalised approaches.
- Use or development of technologies, including AI and wearables, to monitor long-term efficacy and disease progression.
- Use of existing data, biobanks, registries and cohorts, with new data managed under FAIR principles.
- Engagement of patients, caregivers, clinicians and regulators, and use of European research infrastructures.
- Engagement with national public health authorities and regulators.
Projects should liaise with the future European Partnership for Brain Health and should budget for regular joint meetings with other funded projects. The topic requires an effective contribution from the social sciences and humanities.
Expected outcomes
- Scientific and clinical communities use state-of-the-art knowledge, data and tools to develop more effective treatments.
- Data, knowledge and best practices are shared across the EU, Associated Countries and beyond.
- Policymakers, regulators and patient organisations are informed of requirements for wide implementation.
Kaj morate o razpisu vedeti na kratko?
- Proračun teme
- 39.300.000 €
- Sredstva na projekt
- 10.000.000 €
- Oznaka razpisa
- HORIZON-HLTH-2027-02-DISEASE-14-TWO-STAGE
- Program
- Horizon Europe
- Funder
- Horizon Europe, Cluster 1 - Health
- Expected number of projects
- 4
Kdo se lahko prijavi na ta razpis?
- The action type is a Horizon Europe Research and Innovation Action, submitted in two stages.
- Rare neurodegenerative diseases are excluded.
- Participation of start-ups, micro, small and medium-sized enterprises (SMEs) is encouraged.
- The effective contribution of social sciences and humanities disciplines and experts is required.
- Applicants should provide details of their clinical studies in the dedicated annex using the template in the submission system.
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Kdaj je rok za oddajo?
17. februarja 2027 (103 dni)
Two-stage call: first-stage deadline 13 April 2027; second-stage deadline 22 September 2027.
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